in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...

multiple sclerosis (ms) is a demyelinating disease of the central nervous system characterized by morphological hallmarks of inflammation, demyelination and axonal loss. to date, little attention has been paid to the contribution of mitochondrial respiratory chain enzyme activities to ms. in this study, kinetic analysis of mitochondrial respiratory chain complex i enzyme (measured as nadh ferri...

friedreichs ataxia (frda) is an inherited recessive disorder characterized by progressive neurological disability and heart abnormalities. a deficiency in the protein frataxin causes this disease. frataxin deficiency leads to progressive iron accumulation in mitochondria, excessive free radical production and dysfunction of respiratory chain complexes. the expansion (gaa) repeat in the first in...

A Thai plant Clitoria macrophylla Wall. was claimed to possess some pharmacological activities. The phytochemical studies reported a rotenoid compound, 6-deoxyclitoriacetal, which exhibits the cytotoxic effect in several cell line experiments. This report was to study the effect of 6-deoxyclitoriacetal on rat liver mitochondria, which may associated to its cytotoxic phenomena. Mitochondrial sus...

A Thai plant Clitoria macrophylla Wall. was claimed to possess some pharmacological activities. The phytochemical studies reported a rotenoid compound, 6-deoxyclitoriacetal, which exhibits the cytotoxic effect in several cell line experiments. This report was to study the effect of 6-deoxyclitoriacetal on rat liver mitochondria, which may associated to its cytotoxic phenomena. Mitochondrial sus...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

Genetic evidence from recessively inherited Parkinson's disease has indicated a clear causative role for mitochondrial dysfunction in Parkinson's disease. This role has long been discussed based on findings that toxic inhibition of mitochondrial respiratory complex I caused parkinsonism and that tissues of patients with Parkinson's disease show complex I deficiency. Disorders of mitochondrial D...